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The IUBMB Focused Meeting / FEBS Workshop on “Crosstalk between Nucleus and Mitochondria in Human Disease” (CrossMitoNus) will be held in Seville, Spain from May 18th to 21th, 2021. The event will take place at the Research Scientific Centre Isla de la Cartuja. It will provide with an excellent opportunity for a rewarding scientific and personal experience, including exchanging ideas with colleagues and establishing new acquaintances. The Scientific Program is organized in Plenary Lectures, together with sessions containing Oral Short Communications selected from the submitted abstracts.